The nsphs and ncs were prepared using the emulsiondiffusion. Cellulose acetate plasticizer systems tel archives ouvertes. It has therefore found a use in the enteric coating field. Pdf biodegradable nanocomposites of cellulose acetate. Cellulose ac etate phthalate was formulated by dissolving 75 g of cellulose acid hydrogen phthalate eastman kodak, roch ester, n. Pharmaceutics free fulltext design and evaluation of ph.
Medicines are derived from plants and, many of those that are not, are chemicals synthesized to mimic active principles originally purified from plants and used medicinally cellulose acetate phthalate. Cellulose acetate phthalate cap is a commonly used enteric coating polymer. Cellulose acetate phthalate as an enteric coating material. Cellulose acetate phthalate cap is a microbicide which inactivates sexually transmitted disease std pathogens like hiv1. Coating of oral beclomethasone dipropionate capsules with. Cap powder has been studied by various methods to determine characteristics that. Cellulose acetate phthalate 9004380 c116h116o64 sigma. Cellulose acetate phthalate cap, a pharmaceutical excipient used for enteric film coating of capsules and tablets, was shown to inhibit infection by the human immunodeficiency virus type 1 hiv. Dolutegravir dtg is an integrase strand transfer inhibitor with potent antiretroviral activity. Polymers free fulltext cellulose acetate phthalate and. Cellulose acetate phthalate cap, widely used in enteric film coating, is available as a white powder or also as a 30 % solid nanodispersion pseudolatex aquacoat cpd. Recent studies indicate that cellulose acetate phthalate cap, an inactive pharmaceutical excipient commonly used in the production of enteric tablets and capsules, is a broad specificity microbicide against diverse sexually transmitted pathogens. Omc was simultaneously encapsulated in cellulose acetate phthalate nanocapsules and its penetration in the sc was compared to that from a nanoemulsion.
Cellulose acetate phthalate cap is a ph sensitive polymer with hiv1 entry inhibitory properties. Eastman cellulose ester nomenclature eastman cellulose acetates such as ca39810 nfep and ca320s nfep and hydrophobic cellulose acetate butyrate cab17115 nf provide films with a wide range of waterapi permeabilities. Ramsey journal of pharmacology and experimental therapeutics march 1, 1944, 80 3 241249. Nanostructures of cellulose acetate phthalate obtained by. Four groups of 20 female rats each were fed 0, 5, 20 and 30 per cent cellulose acetate phthalate, respectively, for a period of one year. Nanostructures of cap are also prepared, and their potential for antimicrobial and technological applications is recently. Journal of pharmacology and experimental therapeutics march 1944. List item draft guideline on the use of phthalates as excipients in. Cellulose acetate phthalate an overview sciencedirect. Identification of the substancemixture and of the companyundertaking product identifier. Cellulose esters have played a vital role in the development of modern drug delivery technology.
The effect of the plasticizers, triacetin, diacetin, diethyl phthalate, dimethyl phthalate, citroflex. Cap has been used for enteric film coating of tablets and capsules. The presence of second hydrophilic polymer which added into membrane casting solutions plays a crucial role in adjusting the. Treatment of cellulose with nitric acid had produced cellulose nitrate also known as nitrocellulose, but the difficulties of working with this highly flammable compound encouraged research in other areas. Cap is also a vaginal microbicide candidate that potently inhibits hiv1 proliferation. The first page of the pdf of this article appears above. Sep 25, 2001 cellulose acetate phthalate cap is a pharmaceutical excipient which has been used for over four decades for enteric film coating of tablets and capsules. Characterization of cellulose acetate phthalate cap. Abstract at ph values of 24, cellulose acetate phthalate mono layers are uncharged and are arranged in a compact, coherent form. Cellulose acetate was developed in the late 19th century as part of an effort to design industrially produced fibres based on cellulose. Cap formulations inactivated hiv1, herpesvirus types 1 hsv1 and 2 hsv2 and the major nonviral sexually transmitted disease std pathogens and were effective in.
On autopsy, the rats were in good condition and no abnormalities were observed save that the. Electrospinning of cellulose acetate phthalate from different. Electrospinning of cellulose acetate phthalate cap has been performed from an acetone. Cellulose acetate phthalate an overview sciencedirect topics. Soft gelatin films modified with cellulose acetate phthalate. Pdf characterization of cellulose acetate phthalate cap. Also provided is a process for preparing the low viscosity cellulose acetate phthalate polymers. Cellulose acetate phthalate is a cellulose in which some of the hydroxyl groups are acetylated and some are phthalylated. Us5888550a cellulose acetate phthalate enteric coating. Biodegradable nanocomposites of cellulose acetate phthalate and chitosan reinforced with functionalized nanoclay. Cellulose acetate phthalate has been used for enteric coating pharmaceutical dosage forms for many years. Films were made from cellulose triacetate, membranes and. Guideline on the use of phthalates as excipients in human. Improved separation of dyes and proteins using membranes made.
It is inexpensive and generally regarded as a nontoxic material free of adverse effects. Phma7889 cellulose ester blends for tunable drug delivery. Pdf cellulose acetate phthalate cap is a commonly used enteric coating polymer. Addition of plasticizers improves the water resistance of the ester. Enteric esters are those, such as cellulose acetate phthalate. It is a cellulose polymer where about half of the hydroxyls are esterified with acetyls, a quarter are esterified with one or two. Polysulfone psf membrane is catogorized as hydrophobic membrane that easily fouled during membrane operation process. Polymers free fulltext cellulose acetate phthalate. These properties include very low toxicity, endogenous andor dietary decomposition products, stability, high. Effect of ph on monolayers of cellulose acetate phthalate. Abstractcellulose acetate phthalate cap is a commonly used enteric coating polymer. Cap powder has been studied by various methods to determine characteristics that have an influence on its functionality. These properties include very low toxicity, endogenous andor dietary.
Electrospinning of cellulose acetate phthalate from. This work aimed to develop and evaluate phdependent systems based on nanospheres nsphs and nanocapsules ncs loaded with chlorhexidine chx base as a novel formulation for the treatment of periodontal disease. Cellulose acetate phthalate is an enteric polymer and is designated as cap. Cellulose acetate an overview sciencedirect topics. Improved separation of dyes and proteins using membranes. This paper describes the development of a precise, stabilityindicating gel permeation chromatography gpc assay for cap.
Cellulose acetate phthalate definition of cellulose. Recent literature has proved that this polymer exhibits antimicrobial and antiviral properties when it is used as a micronized powder. Nanostructures of cellulose acetate phthalate obtained by electrospinning from 2methoxyethanolcontaining solvent systems. Chemical structure of plasticizers diethyl phthalate and triacetin 33 figure 17. Application cap is used as a stabiling agent in the preparation of pseudolatex. Cpd is a commercial cellulose acetate phthalate cap dispersion widely used for the gastroresistant coating of various solid drug. On autopsy, the rats were in good condition and no abnormalities were observed save that the average stomach weight tended to. Cellulose acetate phthalate is used as an enteric filmcoating material, as a microencapsulation agent, or as a matrix binder for tablets and. A2, and dibutyl tartrate on this property was determined. Eastman cap enteric coating material cellulose acetate phthalate or cellacefate, nf cellulose esters are part of a large family of cellulose derivatives that have a long history of use in pharmaceutical applications. It has been observed that, at low polymer concentration 12.
Sep 25, 2001 cellulose acetate phthalate cap, a pharmaceutical excipient used for enteric film coating of capsules and tablets, was shown to inhibit infection by the human immunodeficiency virus type 1 hiv1 and several herpesviruses. Industrial wastewater often contains xenobiotics such as heavy metals, dyes and proteins, yet there is a lack of efficient cleaning methods. Polyvinyl acetate phthalate is less susceptible to hydrolys is, which minimizes or limits the content of free phthalic acid and other free acids. Cellulose acetate phthalate cap is a pharmaceutical excipient which has been used for over four decades for enteric film coating of tablets and capsules. The rats on high intakes of cellulose acetate phthalate showed a reduction in growth rate which increased with the dosage. Cellulose acetate phthalate cap or cellacefate is a widely polymer used for controlled release formulations in pharmaceuticals rao et al. Development of a gel permeation chromatographic assay to.
Cellulose acetate phthalate, a common pharmaceutical. Enteric coatings of such compositions are more effective than when the ester alone is used. Cellulose acetate phthalate cap was employed as a phdependent polymeric material. Shanbhagt, department of allied health and industrial sciences, college of pharmacy, york 11439, u. Material safety data sheet eastman chemical company. They possess properties that are not only wellsuited to the needs of pharmaceutical applications, but that enable construction of drug delivery systems that address critical patient needs.
Factors influencing the properties of films used for tablet. To adequately reduce new hiv infections, development of highly effective preexposure prophylaxis prep against hiv infection in women is necessary. Pharmaceutics free fulltext design and evaluation of. Stage 6 harmonization official august 1, 2017 cellulose 1 w weight of cellulose acetate taken, calculated cellulose acetate on the dried basis g acceptance criteria. Morphological aspects, thermal behavior, and antimicrobial activity. Cellulose acetate material safety data sheet cas no 9004357.
Cellulose acetate phthalate cap manufacturers, suppliers. The cellulose acetate phthalates have an inherent viscosity of about 0. This ester and its salts have been disclosed in patents by malm and waring 5 and have. These shown cellulose acetate phthalate manufacturing companies are known for its product quality. Cellulose acetate phthalate cap, also known as cellacefate and cellulosi acetas phthalas, is a commonly used polymer phthalate in the formulation of pharmaceuticals, such as the enteric coating of tablets or capsules and for controlled release formulations. Cellulose acetate phthalate is soluble in buffer solutions at ph values as low as 6. Nanostructures of cap are also prepared, and their potential for antimicrobial and technological applications is.
Material safety data sheet section 1 cellulose acetate phthalate 1 chemical product and company identification msds name. Guideline on the use of phthalates as excipients in human medicinal. Cellulose beads are regenerated cellulose of the modi. Cellulose acetate phthalate cap, a pharmaceutical excipient used for enteric film coating of capsules and tablets, was shown to inhibit infection by the human immunodeficiency virus type 1. Specified substances cellacefate cellulose acetate phthalate no data available. Pharmaceutical applications of plasticized polymers. The nsphs and ncs were prepared using the emulsiondiffusion technique and then characterized according to encapsulation efficiency ee, size, zetapotential, morphology, thermal properties, release profiles and a preliminary clinical panel test. Cellulose acetate phthalate definition of cellulose acetate. Product name, description empirical formula hill notation. Hydroxypropyl methylcellulose acetate phthalate hpmcp. Therefore, here we fabricated hollow fiber membranes using polyphenylsulfone containing 1, 3 and 5 wt% of cellulose acetate and cellulose acetate phthalate by nonsolvent induced phase separation. Depending on its processing, cellulose acetate can be used for different applications. The water vapor transmission of thin plasticized cellulose acetate phthalate films was studied at 90, 76, and 52 per cent relative humidities.
Central drug house p ltd 728 vardaan house new delhi2 india. Cellulose acetate phthalate cap is wellknown and largely used as a pharmaceutical excipient for enteric coating of tablets and capsules. It is a cellulose polymer where about half of the hydroxyls are esterified with acetyls, a quarter is esterified with one or two carboxyls of a phthalic acid, and the. Here is the listings of cellulose acetate phthalate cas 9004380, cellulose acetate phthalate manufacturers, suppliers and exporters.